WebA phase 1 open-label, 2-period, fixed-sequence, 2-part study (NCT03928327) characterized effects of a strong CYP3A4 inhibitor (itraconazole) and inducer (rifampin) on the pharmacokinetics (PK) of mobocertinib and its active metabolites, AP32960 and AP32914. Healthy volunteers (n = 12 per part) received a single dose of mobocertinib alone (20 mg ... WebJul 14, 2024 · The College on Problems of Drug Dependence (CPDD), the oldest and largest organization dedicated to research on substance use disorders, has been …
Understanding the Review Process National Institute of …
WebThis was a phase I, open-label, parallel-group, multicenter study conducted in 8 participants with severe renal impairment (creatinine clearance <30 mL/min; no renal replacement … WebApr 4, 2024 · Review Branches. Review activities of the Center for Scientific Review (CSR) are organized into Review Branches (RBs). Each RB represents a cluster of study … cms status code t
Should We Keep Meeting This Way? – NIH …
WebJan 18, 2024 · The Biobehavioral Processes (BP) Review Branch considers applications on biobehavioral and behavioral processes across the lifespan as related to higher cognitive functions, mental and physical health, and psychological and physical disorders. Research on animals as well as humans is included, both normal and disordered processes are … WebDOI: 10.1002/cpdd.1082 Abstract Belumosudil is a selective Rho-associated protein kinase 2 inhibitor. ... As such, this 2-part clinical drug-drug interaction study was conducted to assess the effect of itraconazole (a strong CYP3A4 inhibitor), rifampicin (a strong CYP3A4 inducer), rabeprazole, and omeprazole (both proton pump inhibitors) on the ... WebJun 13, 2024 · Scientific Review Officer. [email protected]. 301-443-9485. Reporting Avenues for Concerns Related to Integrity or Fairness. The Child Psychopathology and Developmental Disabilities Study Section focuses on human subject studies of … Shared Interests and Overlaps. Applications with a focus on behavioral mechanisms … PDRP - CPDD NIH Center for Scientific Review - National Institutes of Health Shared Interests and Overlaps. Applications related to the motoric/articulatory … Mesh - CPDD NIH Center for Scientific Review - National Institutes of Health Npas - CPDD NIH Center for Scientific Review - National Institutes of Health Shared Interests and Overlaps. Neurogenesis and Cell Fate Study … cms status indicator k