Ctbp/bars
WebThe ANGUSTIFOLIA (AN) gene in Arabidopsis thaliana (L.) Heynh. is the first homolog of the CtBP/BARS gene family identified in plants and is responsible for the polarity-dependent control of leaf cell expansion. This review compares the sequence homology and functional similarity of the AN protein with authentic animal CtBP/BARS family proteins. C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2. See more The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional See more CTBP1 has been shown to interact with: • ACTL6B, • ARF, • EVI1 • FOXP2, See more • Human CTBP1 genome location and CTBP1 gene details page in the UCSC Genome Browser. • Overview of all the structural information available in the PDB for See more • Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. See more
Ctbp/bars
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WebJun 13, 2024 · The ANGUSTIFOLIA (AN) gene in Arabidopsis is important for a plethora of morphological phenotypes. Recently, AN was also reported to be involved in … WebMay 14, 2013 · Previous sequence comparison studies demonstrated that the plant AN gene encodes a protein related to C-terminal binding protein/brefeldin A ADP-ribosylated substrate (CtBP/BARS) with an important role in animal development [12, 13], and an encoded protein thought to repress transcription in a manner similar to that of animal …
WebJun 16, 2003 · The structural data show CtBP/BARS in a NAD(H)-bound dimeric form; the peptide binding maps the recognition site for DNA-binding proteins and histone … WebMar 1, 2006 · CtBP/BARS was originally identified as a ‘brefeldin A (BFA)-dependent ADP-ribosylation substrate’ during a search for factors that control membrane tubulation 15, 16. BFA is a fungal toxin that promotes the disassembly of the Golgi complex into tubules. Although BFA was known to block the GTP exchange factor for the small GTPase Arf, …
WebCtBP proteins can also self-associate and presumably bring together gene regulatory complexes. ... CTBP/BARS: A DUAL-FUNCTION PROTEIN INVOLVED IN TRANSCRIPTION COREPRESSION AND GOLGI MEMBRANE FISSION PDB 1hl3 EBI.jpg. 1hl3: CTBP/BARS IN TERNARY COMPLEX WITH NAD(H) AND PIDLSKK PEPTIDE WebAug 4, 2024 · CtBP, a transcriptional cofactor displaying high expression in a variety of human cancers, has become one of the main targets for cancer prediction, diagnosis, and treatment. ... Scale bar: 100 ...
WebCtBP/BARS is a unique protein family in having quite diversified cellular functions, intercellular localizations, and developmental roles. ANGUSTIFOLIA (AN) is the sole …
WebThe C terminal-binding protein (CtBP) family functions in the nucleus as co-repressors of transcription and has a crucial role in differentiation, apoptosis, oncogenesis and … npr news afghanistanWebOct 8, 2024 · Here, through a genetic screen in Arabidopsis thaliana, we demonstrated that loss-of-function mutations in ANGUSTIFOLIA ( AN ), which encodes a homolog of mammalian CtBP/BARs, resulted in swollen conical cells, correlating with increased accumulation of reactive oxygen species (ROS). npr new jersey electionWebMar 27, 2009 · C-terminal binding proteins (CtBPs) are multi-functional proteins involved in nuclear transcriptional co-repression, Golgi membrane fission, and synaptic ribbon formation. Binding of NAD(H) to CtBPs promotes dimerization.CtBP dimers act as a scaffold for multimeric protein complex formation, thus bridging transcriptional repressors and … npr new jersey stationsWebBARS; Brefeldin A-Ribosylated Substrate; C-Terminal Binding Protein 1; C-Terminal-Binding Protein 1; CTBP; CTBP1; CtBP1; Description From NCBI Gene: This gene encodes a … npr new jersey governor raceWebJun 16, 2003 · The structural data show CtBP/BARS in a NAD(H)-bound dimeric form; the peptide binding maps the recognition site for DNA-binding proteins and histone deacetylases to an N-terminal region of the protein. The crystal structure together with the site-directed mutagenesis data and binding experiments suggest a rationale for the molecular … npr new partsWebMar 15, 2002 · The ANGUSTIFOLIA (AN) gene is required for leaf hair (trichome) branching and is also involved in polarized expansion underlying organ shape.Here we show that … night buddy headlamp reviewWebCtBP3/BARS was the third protein of the CtBP (C-terminal binding protein) family to be identified. It was initially isolated as a 50-kDa cytosolic protein during the characterisation of the molecular targets of the toxin brefeldin … npr new music