2024 Rkip and yy1 international symposium

Rkip and yy1 international symposium

Author: rexg

August undefined, 2024

WebFeb 1, 2024 · The Raf Kinase Inhibitory Protein (RKIP), is a tumor suppressor and immune enhancer often found downregulated in the majority of the examined cancers. In the present report, the role of both YY1 and RKIP in LC is thoroughly explored through the analysis of several deposited RNA and protein expression datasets. WebMay 5, 2024 · The human RKIP gene is located on chromosome 12q24 and contains a promoter region with several sequences involved in the regulation of RKIP transcription, such as the E1-Box, E2-Box, CpG islands, and androgen-response elements (ARE) [21,22,23].Like many proteins, RKIP can undergo post-translational phosphorylation …

RKIP and YY1 Symposium 2024 - Registration

WebDec 11, 2024 · Of interest, a follow up of these contributions above can be followed in a forthcoming International Conference titled “ Prognostic and Therapeutic Implications of … fip probe

Overexpression of RKIP and its cross-talk with several regulatory …

WebFeb 12, 2024 · The computational analyses revealed that YY1 negatively regulates RKIP expression in LC, as corroborated by the deposited YY1-ChIP-Seq experiments and … WebYY1’s negative regulation of RKIP and vice versa. In these roads, YY1 represents the green traffic light (green lines) which promotes cancer properties, including tumor spreading and resistance to therapy, whereas RKIP acts as the red traffic light (red lines) that stops tumor functions. Accordingly, the YY1/RKIP motif may serve as a potent ... WebMay 1, 2007 · The metastatic suppressor gene Raf kinase inhibitor protein (RKIP), has been reported to inhibit NF-κB activity (Yeung et al.,1999,2000). Therefore, we hypothesized that NO may induce RKIP expression leading to inhibition of NF-κB and YY1 and upregulation of DR5, leading to sensitization to TRAIL-induced apoptosis. essential oils for injured shoulder

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Joint International Symposium - st PROGNOSTIC AND …

WebOn the same context, we have previously identified the critical role of YY1 as a mediator of tumor resistance to both chemo-and immunomediated apoptosis in various cancer … WebInternational Journal of Cell Biology. 2012. 2012. A new model for raf kinase ... Dual role of NO donors in the reversal of tumor cell resistance and EMT: dysregulation of the NF-kappa B/YY1/Snail/RKIP circuitry. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. S18-S18. Full Text via DOI: 10.1016/j.niox.2010.05. ... essential oils for internal inflammationWebJan 11, 2024 · YY1, discovered in the early 1990s by several groups using a variety of approaches 1-5 is a member of the GLI-Kruppel family of zinc finger DNA binding proteins that can activate or inactivate gene expression depending on partner proteins, promoter context and chromatin structure. 6 YY1 has activity that is dependent 6, 7 and … fip promo

"WebHome. Welcome to the RKIP and YY1 Symposium 2024 in Catania, Sicily (Italy) Dear Colleagues, It is our great pleasure to invite you to join the 1st Joint International … The First International Conference on “Prognostic and Therapeutic Roles of Yin … " - Rkip and yy1 international symposium

Rkip and yy1 international symposium

The biological complexity of RKIP signaling in human cancers

WebJul 29, 2024 · The ‘International Symposium on Managing Land and Water for Climate-Smart Agriculture’ aims to facilitate the exchange of information and knowledge among soil, water and environment professionals from developed and developing countries to advance the understanding, collaboration and capabilities to respond to the impact of climate … WebMarch 8-11, 2024 - RKIP and YY1 Symposium 2024. March 8-11, 2024 - RKIP and YY1 Symposium 2024. Registration form deadline: January 31st, 2024. First Name * Last Name * Email Address * Telephone Number * -Country code number. Address . …

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WebFeb 3, 2024 · Description. Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression … WebWe evaluated the RKIP and pRKIP protein by immunohistochemistry in control skin, pigmented nevi and melanomas, and through Western blotting in human normal melanocytes and in four different ...

WebSep 30, 2024 · First described in 1991, Yin Yang 1 (YY1) is a transcription factor that is ubiquitously expressed throughout mammalian cells. It regulates both transcriptional activation and repression, in a seemingly context-dependent manner. YY1 has a well-established role in the development of the central nervous system, where it is involved in … WebThis review discusses the molecular regulation of EMT in cancer cells through the activity of the dysregulated NF-κB/Snail/ YY1/PTEN/RKIP circuitry. In addition, we propose YY1 as a potential novel prognostic biomarker for EMT and a therapeutic target for both the prevention of metastasis and the reversal of resistance.

WebChiefly, these findings suggest that targeted inhibition of YY1 by specific small molecule inhibitors and/or the specific induction of RKIP expression and activity are potential … WebJan 31, 2014 · The presence of a dysregulated NF-κB/Snail/YY1/RKIP loop was recently established in metastatic prostate cancer cells and non-Hodgkin’s lymphoma; however, its involvement in multiple myeloma (MM) has yet to be investigated. Aim of the study was to investigate the role of the NF-κB/Snail/YY1/RKIP circuitry in MM and how each gene is …

WebJul 18, 2024 · Raf Kinase Inhibitory Protein (RKIP) is a highly conserved kinase inhibitor that functions as a metastasis suppressor in a variety of cancers. Since RKIP can reprogram tumor cells to a non-metastatic state by rewiring kinase networks, elucidating the mechanism by which RKIP acts not only reveals molecular mechanisms that regulate …

WebJan 31, 2014 · The present study highlights the relationships of the NF-κB/Snail/YY1/RKIP circuitry genes with specific cancer-related gene sets in multiple myeloma. The presence of a dysregulated NF-κB/Snail/YY1/RKIP loop was recently established in metastatic prostate cancer cells and non-Hodgkin’s lymphoma; however, its involvement in multiple myeloma … fip propertiesWebContrarily, the induction of RKIP downregulates NF-κB signaling and thus inhibits YY1 and Snail 1. At the same time, the expression of PTEN inhibits the PI3K/AKT (phosphoinositide-3-kinase/AKT) pathway ( Figure 2 ) leading to a significant inhibition of AKT-mediated signaling pathway, but also to autophagy proteins such as LC3-I/II, LAMP, cathepsin B, … essential oils for internal shinglesWebThe First International Conference on “Prognostic and Therapeutic Roles of Yin Yang 1 in Cancer” (Catania, Italy May 24-26, 2009) and The Second International Conference on … fipps 100WebNov 22, 2024 · Raf kinase inhibitor protein (RKIP), an important modulator of intracellular signalling pathways, is commonly downregulated in multiple cancers. This reduction, or … fipps bayernWeb1st Joint International Symposium PROGNOSTIC AND THERAPEUTIC IMPLICATIONS OF RKIP AND YY1 IN CANCER, DIABETES AND CARDIOVASCULAR DISEASES March 11, 2024 … essential oils for insomnia and anxietyWebNov 20, 2024 · Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional activation and repression of many genes associated with multiple cellular processes including cellular differentiation, DNA repair, autophagy, cell survival vs. apoptosis, and cell division. Owing to its role in processes that upon deregulation are … fipps a-130WebJan 1, 2024 · The RKIP/Raf interaction is regulated by RKIP phosphorylation at Ser-153 as well as occupancy of the ligand binding domain of RKIP by a phospholipid or other ligands … essential oils for intestinal gas