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Tfeb s142

Web7 Oct 2024 · Although the cytoplasm retention of TFEB is well documented, and it occurs through phosphorylation events, once TFEB has been translocated to the nucleus and … Web28 May 2024 · erk2是细胞生长的主调节因子，在富营养条件下磷酸化tfeb。erk2在s142位点磷酸化tfeb促进tfeb的胞质保留，而抑制erk2促进tfeb的核定位（图5）。 tfeb也可以 …

TFEB: A Emerging Regulator in Lipid Homeostasis for …

Web17 Feb 2024 · The structure and function of TFEB in lipid homeostasis. TFEB is a protein consisting of 476 amino acid residues, mainly including glutamine-rich (GIn rich), an … Web(A–C) NRCMs were treated with 5 µM Scrambled or Tat-Beclin 1 for 6 h and analyzed via Western blotting using anti-Tfeb, anti-pTfeb (Ser142) and anti-Gapdh antibodies (A) The … cab bible translation https://aksendustriyel.com

mTOR-dependent phosphorylation controls TFEB nuclear export.

WebThe induction of senescence/polyploidization and their role in cancer recurrence is still a poorly explored issue. We showed that MDA-MB-231 and MCF-7 breast cancer cells underwent reversible senescence/polyploidization upon pulse treatment with doxorubicin (dox). Subsequently, senescent/polyploid cells produced progeny (escapers) that … WebThe activity of TFEB is tightly linked to nutrient availability via protein phosphorylation. In the presence of nutrients TFEB is phosphorylated by mTOR on S142 and S211 serine … WebThe O/A-dependent decrease in phospho-S142 corresponds with the shift in MM of TFEB caused by O/A alone and may be the result of the O/A-dependent effects on both AMPK and mTORC1 activity, which likely reflect a loss of mitochondrial function that is independent of mitophagy. Thus, phosphorylation changes at S142 and S211 alone are not sufficient to … cabber machine

TFEB; Beyond Its Role as an Autophagy and Lysosomes …

Category:mTOR-dependent phosphorylation controls TFEB nuclear export

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Tfeb s142

TFEB acetylation promotes lysosome biogenesis and

WebS138 and S142 are localized in the proximity of a NES. (B) S138 and S142 of TFEB are evolutionarily conserved in the indicated species. Alignment of the sequences near TFEB … Web1 Dec 2024 · According to previous studies, S122, S134, S138, S142, S211, and S467 are crucial phosphorylated sites on TFEB ( 16 ). As aforementioned, the transcription repressor ZKSCAN3 also regulates lysosome biogenesis and …

Tfeb s142

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Web8 Sep 2024 · tfeb在s142的磷酸化还由erk2介导。 图4 tfeb 结构域结构中的磷酸化位点及其调节作用. 最近研究还发现stub1通过靶向磷酸化的tfeb(s142和s211)进行泛素介导的蛋白酶 … WebAnti-phospho TFEB (Ser142), Cat. No. ABE1971-I, is a highly specific rabbit polyclonal antibody that targets Transcription factor EB phosphorylated on Serine 142 and has been …

WebPolyclonal Antibody for studying TFEB (Ser122) phosphate. Cited in 6 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in … Web15 May 2024 · The MiT-TFE family of basic helix-loop-helix leucine-zipper transcription factors includes four members: TFEB, TFE3, TFEC, and …

Web28 Feb 2024 · Approach and Results— Endothelial denudation shows that TFEB is mainly expressed in ECs in mouse aortas. Western blotting shows TFEB total protein level … WebS211 in TFEB is responsible for phosphorylation-dependent interaction with YWHA/14-3-3 proteins. It has been reported that phosphorylation of TFEB at S142 and/or S211 is …

Web20 Nov 2024 · As expected, in TFEB-GFP HeLa cells treated with STV, TFEB p-S142 levels were reduced (Figure 3 B). We obtained the same results when cells were treated with …

Web12 Jul 2024 · Overexpression of TFEB with serine to alanine mutation at the mTORC1-dependent phosphorylation sites (S142, S211, and S142/S211) resulted in nuclear localization of TFEB in both TSC2 -expressing and TSC2 -deficient HeLa cells (Supplementary Fig. 3 ). cabbi bed and breakfastWebFig. 8 TFEB S142 phosphorylation confers BRAFi resistance in melanoma cells. a Representative images (left) and quantification (right) of the colonogenic survival of A375 … clover twigWebS142 The 2-year follow-up results of lyso-GB3 levels in patients with Fabry disease. Turkmen, Kultigin / Selcuk, Nedim Yılmaz / Tonbul ... Genistein activates TFEB and induces lysosomal clearance in Niemann-Pick disease type C … clover turn off two factor authenticationWeb电话: 400-999-6126; 邮箱: [email protected]; 地址: 武汉市东湖高新区生物园三路高科园三路9号武汉精准医疗产业基地 clover tungWebTFEB has also been shown to be activated in a nutrient-dependent manner by p42 MAP kinase (Erk2). TFEB is phosphorylated at Ser142 by Erk2 in response to nutrient … cab bernina dealer sell on ebay amazonhttp://www.suzhouwomei.com/index.php?c=show&id=347 cabberras near meWebTat-Beclin1-induced autosis is regulated by Tfeb modulation in NRCMs. (A–C) NRCMs were treated with 5 µM Scrambled or Tat-Beclin 1 for 6 h and analyzed via Western blotting … cabbets with a thick thread