Top2a breast cancer
Web11. apr 2024 · HIGHLIGHTS. who: David Barua from the MCF7, T D, and , cells were procured from ECACC (Salisbury, Sussex, UK), cells expressing Y S and D G mutants were kind gifts from Dr. Steffi Oesterreich (University of Pittsburgh, USA). HEK , T cells were obtained from the Indiana University National Gene Vector Biorepository (Indianapolis, IN, USA). Cells … Web20. nov 2006 · The tumours with a TOP2A amplification contributed hardly to this difference, suggesting that TOP2A amplification is not the cause of the steep dose-response curve for anthracyclines in breast cancer. Possibly, the difference of the cumulative dose of only 25% between the treatment arms was insufficient to yield a survival difference. Publication
Top2a breast cancer
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Web1. júl 2024 · Expression analysis of TOP2A in various cancers. (A) The expression of the TOP2A in 18 cancer types with 5 or more normal tissues from TCGA project via R. (B) The … Web15. mar 2007 · The TOP2A gene is located adjacent to HER2 on chromosome 17q. TOP2A encodes topoisomerase IIα (topoIIα), an enzyme involved in DNA replication that is the …
Web20. feb 2010 · Ejlertsen et al. [25] showed that TOP2A was a direct molecular target of anthracyclines that can improve the sensitivity of anthracycline-containing chemotherapy in high-risk breast cancer ... Web1. júl 2024 · TOP2A expression was generally positively correlated with cancer associated fibroblasts, M0 and M1 macrophages in most cancer types. Furthermore, TOP2A was …
Web11. sep 2024 · De Resende et al have reported that high expression of TOP2A protein is associated with severe lymphatic vascular invasion and a low relapse-free survival rate in … WebTOP2, TP2A. Topoisomerase (DNA) II alpha (TOP2A) is a gene that encodes a protein that controls and alters topologic states of DNA during transcription. Missense mutations, …
Web14. apr 2010 · Our study suggests that TOP2A RNA levels are associated with prognosis and the responses of breast cancer patients to treatment. We therefore support the …
WebTOP2A is highly expressed in proliferating and growing cells. It is also detected in diverse human malignancies such as adrenocortical, nasopharyngeal, primary breast cancer and … st vincent\u0027s gynecology birmingham alWebHigh expression of TOP2A in many types of tumors, such as non-small cell lung cancer, hepatocellular carcinoma, and breast cancer, has been proven to be a dependable proliferation marker and is ... st vincent\u0027s haematology clinicWeb1. apr 2024 · Download Citation On Apr 1, 2024, Yang Fu and others published Circular RNA Ubiquitin-associated Protein 2 Silencing Suppresses Bladder Cancer Progression by Downregulating DNA Topoisomerase 2 ... st vincent\u0027s hand specialistWeb15. jan 2024 · TOP2A may be a new biomarker and therapeutic target for hepatocellular carcinoma. Introduction Hepatocellular carcinoma (HCC) is a malignant form of primary liver cancer. st vincent\u0027s health australia ltdWeb1. jan 2024 · TOP2A is an enzyme that controls the topological states of DNA. It catalyzes double-strand DNA breaking and promotes gene transcription during mitosis [3]. It has … st vincent\u0027s happy hollow rd trussville alWebPred 1 dňom · Anthracycline plus taxane regimens are most efficacious at reducing breast cancer recurrence and death. Regimens with higher cumulative doses of anthracycline plus taxane provide the greatest benefits, challenging the current trend in clinical practice and … st vincent\u0027s health emailWeb3. júl 2024 · BG induced MGMT inhibition leads to inhibition of CDC2, TOP2A, AURKB, KIF20A, CDC20 expression. : Benzylguanine sensitizes breast cancer cells to temozolomide BG+/-TMZ therapy decrease CDC2,... st vincent\u0027s health melbourne